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KMID : 0371420140860030143
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Annals of Surgical Treatment and Research
2014 Volume.86 No. 3 p.143 ~ p.151
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Predictive factors and the prognosis of recurrence of colorectal cancer within 2 years after curative resection
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Ryuk Jong-Pil
Choi Gyu-Seog
Park Jun-Seok
Kim Hye-Jin
Park Soo-Yeun
Yoon Ghil-Suk
Jun Soo-Han
Kwon Yong-Chul
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Abstract
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Purpose: Because predicting recurrence intervals and patterns would allow for appropriate therapeutic strategies, we evaluated the clinical and pathological characteristics of early and late recurrences of colorectal cancer.
Methods: Patients who developed recurrence after undergoing curative resection for colorectal cancer stage I-III between January 2000 and May 2006 were identified. Early recurrence was defined as recurrence within 2 years after primary surgery of colorectal cancer. Analyses were performed to compare the clinicopathological characteristics and overall survival rate between the early and late recurrence groups.
Results: One hundred fifty-eight patients experienced early recurrence and 64 had late recurrence. Multivariate analysis revealed that the postoperative elevation of carbohydrate antigen 19-9 (CA 19-9), venous invasion, and N stage correlated with the recurrence interval. The liver was the most common site of early recurrence (40.5%), whereas late recurrence was more common locally (28.1%), or in the lung (32.8%). The 5-year overall survival rates for early and late recurrence were significantly different (34.7% vs. 78.8%; P < 0.001). Survival rates after the surgical resection of recurrent lesions were not different between the two groups.
Conclusion: Early recurrence within 2 years after surgery was associated with poor survival outcomes after colorectal cancer recurrence. An elevated postoperative CA 19-9 level, venous invasion, and advanced N stage were found to be significant risk factors for early recurrence of colorectal cancer.
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KEYWORD
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Colorectal neoplasms, Recurrence interval, Risk factors, Recurrence, Survival
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